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Invitrogen™ TNP2 Polyclonal Antibody
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Catalog No. PIPA5103981
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100 μL
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PIPA5103981 100 μL
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Catalog No. PIPA5103981 Supplier Invitrogen™ Supplier No. PA5103981
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total TNP2.

During mammalian spermiogenesis, histones are transiently replaced by several low molecular weight proteins called transition proteins (TNPs) . Transition proteins facilitate chromatin transformation from the nucleosome structure to the nucleoprotamine structure during spermatid differentiation . Transition protein-2, also known as TNP2, and TP2, maps to human chromosome 16p13.13 and encodes a highly basic nuclear protein. TNP2 is a spermatid-specific product of the haploid genome which replaces histone and is itself replaced in the mature sperm by the protamines . TNP2 is not a critical factor for shaping of the sperm nucleus, histone displacement, initiation of chromatin condensation, binding of protamines to DNA, or fertility . However, TNP2 is necessary for maintaining the normal processing of protamine 2 and, consequently, the completion of chromatin condensation. If TNP1 is missing, TNP2 may partially compensate for TNP1, but this dysregulation of nucleoprotein replacement results in an abnormal pattern of chromatin condensation and in reduced fertility .
TRUSTED_SUSTAINABILITY

Specifications

Antigen TNP2
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene TNP2
Gene Accession No. Q05952
Gene Alias haploid expressed, male germcell specific, chromatin binding; nuclear transition protein 2; TNP2; TP2; TP-2; transition protein 2; transition protein 2 (during histone to protamine replacement)
Gene Symbols TNP2
Host Species Rabbit
Immunogen A synthesized peptide derived from human TNP2(Accession Q05952), corresponding to amino acid residues Q39-H89.
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 7142
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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