Invitrogen™ TNPO2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA567176

Catalog No. PIPA567176

Description

Immunogen sequence: QDIKPRFHKSR TVTLPHEAER PDGSEDAEDD DD Highest antigen sequence identity to the following orthologs - mouse 94%, rat 97%.

Probably functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.

Specifications

• Antigen: TNPO2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: TNPO2
• Gene Alias: 1110034O24Rik; AA414969; AI464345; AI852433; importin 3; IPO3; karyopherin (importin) beta 2b; karyopherin beta 2b, transportin; karyopherin beta-2b; Knpb2b; Kpnb2b; TNPO2; transportin 2; transportin 2 (importin 3, karyopherin beta 2b); transportin-2; TRN2
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 30000
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunocytochemistry
• Concentration: 0.05 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: O14787
• Gene Symbols: TNPO2
• Immunogen: Recombinant Human TNPO2. Recombinant protein control fragment (Product #RP-107820).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG