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Invitrogen™ TNPO3 Recombinant Rabbit Monoclonal Antibody (0U3Q1)
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Catalog No. PIMA537991
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PIMA537991 100 μL
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Catalog No. PIMA537991 Supplier Invitrogen™ Supplier No. MA537991
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Description

Rabbit Recombinant Monoclonal Antibody

Positive Samples: HeLa, RD, Jurkat, Mouse lung, Mouse testis, Mouse thymus, Rat testis Immunogen sequence: QVMNQLGQQL VSQLLHTCCF CLPPYTLPDV AEVLWEIMQV DRPTFCRWLE NSLKGLPKET TVGAVTVTHK QLTDFHKQVT SAEECKQVCW ALRDFTRLFR.

TNPO3 is a member of the importin beta/transportin family of nuclear import receptors and is specific for the essential splicing factors termed SR proteins, binding specifically and directly to the arginine/serine (RS)-rich domains of these proteins. Further experiments demonstrated that this interaction occurs only when these RS domains are phosphorylated. More recently, TNPO3 was identified as an HIV dependency factor (HDF) and that depletion of TNPO3 resulted in HIV inhibition after reverse transcription but before integration, suggesting that TNPO3 may be an important drug target in HIV treatment. At least three isoforms of TNPO3 are known to exist.
TRUSTED_SUSTAINABILITY

Specifications

Antigen TNPO3
Applications ELISA, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Recombinant Monoclonal
Clone 0U3Q1
Concentration 1.65 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.05% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Gene TNPO3
Gene Accession No. Q6P2B1, Q9Y5L0
Gene Alias 5730544L10Rik; C430013M08Rik; C81142; D6Ertd313e; Imp12; importin 12; Importin-12; IPO12; LGMD1F; limb girdle muscular dystrophy 1F (autosomal dominant); mKIAA4133; MTR10A; Tnpo3; transportin 3; transportin-3; Transportin-SR; TRNSR; TRN-SR; TRN-SR2
Gene Symbols TNPO3
Host Species Rabbit
Immunogen A synthetic peptide corresponding to a sequence within amino acids 824-923 of human Transportin 3 (Transportin 3 (TNPO3)) (Q9Y5L0).
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 23534, 296954, 320938
Target Species Human, Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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