Invitrogen™ TNPO3 Recombinant Rabbit Monoclonal Antibody (JG38-77)

Rabbit Recombinant Monoclonal Antibody

Supplier:  Invitrogen™ MA534790

Catalog No. PIMA534790

Description

Positive Control: HL-60, mouse pancreas tissue lysate, A549, SH-SY-5Y, SiHa, human liver cancer tissue, human small intestine tissue, mouse lung tissue, mouse kidney tissue.

TNPO3 is a member of the importin beta/transportin family of nuclear import receptors and is specific for the essential splicing factors termed SR proteins, binding specifically and directly to the arginine/serine (RS)-rich domains of these proteins. Further experiments demonstrated that this interaction occurs only when these RS domains are phosphorylated. More recently, TNPO3 was identified as an HIV dependency factor (HDF) and that depletion of TNPO3 resulted in HIV inhibition after reverse transcription but before integration, suggesting that TNPO3 may be an important drug target in HIV treatment. At least three isoforms of TNPO3 are known to exist.

Specifications

• Antigen: TNPO3
• Classification: Recombinant Monoclonal
• Concentration: 1 mg/mL
• Formulation: TBS with 0.05% BSA, 40% glycerol and 0.05% sodium azide; pH 7.4
• Gene Accession No.: Q6P2B1, Q9Y5L0
• Gene Symbols: TNPO3
• Immunogen: Recombinant protein within Human TNPO3 aa 830-923.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Clone: JG38-77
• Conjugate: Unconjugated
• Gene: TNPO3
• Gene Alias: 5730544L10Rik; C430013M08Rik; C81142; D6Ertd313e; Imp12; importin 12; Importin-12; IPO12; LGMD1F; limb girdle muscular dystrophy 1F (autosomal dominant); mKIAA4133; MTR10A; Tnpo3; transportin 3; transportin-3; Transportin-SR; TRNSR; TRN-SR; TRN-SR2
• Host Species: Rabbit
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 23534, 296954, 320938
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles, store in dark
• Form: Liquid