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Invitrogen™ TOB1 Polyclonal Antibody
Rabbit Polyclonal Antibody
Supplier: Invitrogen™ PA565480
Description
Immunogen sequence: STKMKNSGRSN KVARTSPINL GLNVNDLLKQ KAISSSMHSL YGLGLGSQQQ PQQQ Highest antigen sequence identity to the following orthologs - mouse 91%, rat 91%.
This gene encodes a member of the tob/btg1 family of anti-proliferative proteins that have the potential to regulate cell growth. When exogenously expressed, this protein supresses cell growth in tissue culture. The protein undergoes phophorylation by a serine/threonine kinase, 90 kDa ribosomal S6 kinase. Interactions of this protein with the v-erb-b2 erythroblastic leukemia viral oncogene homolog 2 gene product p185 interferes with growth suppression. This protein inhibits T cell proliferation and transcription of cytokines and cyclins. The protein interacts with both mothers against decapentaplegic Drosophila homolog 2 and 4 to enhance their DNA binding activity. This interaction inhibits interleukin 2 transcription in T cells.
Specifications
TOB1 | |
Polyclonal | |
Unconjugated | |
TOB1 | |
APRO5; APRO6; MGC104792; MGC34446; PIG49; proliferation-inducing gene 49; protein Tob1; Protein Tob1-like protein; TOB; TOB1; transducer of erbB2; Transducer of erbB-2 1; transducer of ERBB2, 1; transducer of ErbB-2.1; Trob; TROB1; Unknown (protein for MGC:134447) | |
Rabbit | |
Antigen affinity chromatography | |
RUO | |
10140 | |
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
Liquid |
Immunohistochemistry (Paraffin), Immunocytochemistry | |
0.1 mg/mL | |
PBS with 40% glycerol and 0.02% sodium azide; pH 7.2 | |
P50616 | |
TOB1 | |
Recombinant Human TOB1. Recombinant protein control fragment (Product #RP-106155). | |
100 μL | |
Primary | |
Human | |
Antibody | |
IgG |
Safety and Handling
WARNING: Cancer - www.P65Warnings.ca.gov
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