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Invitrogen™ TOB1 Polyclonal Antibody
Rabbit Polyclonal Antibody
Supplier: Invitrogen™ PA568791
Description
This target displays homology in the following species: Cow: 93%; Dog: 93%; Horse: 93%; Human: 93%; Mouse: 100%; Pig: 93%; Rat: 93%.
This gene encodes a member of the tob/btg1 family of anti-proliferative proteins that have the potential to regulate cell growth. When exogenously expressed, this protein supresses cell growth in tissue culture. The protein undergoes phophorylation by a serine/threonine kinase, 90 kDa ribosomal S6 kinase. Interactions of this protein with the v-erb-b2 erythroblastic leukemia viral oncogene homolog 2 gene product p185 interferes with growth suppression. This protein inhibits T cell proliferation and transcription of cytokines and cyclins. The protein interacts with both mothers against decapentaplegic Drosophila homolog 2 and 4 to enhance their DNA binding activity. This interaction inhibits interleukin 2 transcription in T cells.
Specifications
TOB1 | |
Polyclonal | |
Unconjugated | |
TOB1 | |
APRO5; APRO6; MGC104792; MGC34446; PIG49; proliferation-inducing gene 49; protein Tob1; Protein Tob1-like protein; TOB; TOB1; transducer of erbB2; Transducer of erbB-2 1; transducer of ERBB2, 1; transducer of ErbB-2.1; Trob; TROB1; Unknown (protein for MGC:134447) | |
Rabbit | |
Protein A | |
RUO | |
22057 | |
-20°C, Avoid Freeze/Thaw Cycles | |
Liquid |
Western Blot | |
1.0 mg/mL | |
PBS with 2% sucrose and 0.09% sodium azide | |
Q61471 | |
TOB1 | |
synthetic peptide directed towards the middle region of mouse TOB1. | |
100 μL | |
Primary | |
Mouse | |
Antibody | |
IgG |
Safety and Handling
WARNING: Cancer - www.P65Warnings.ca.gov
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