Invitrogen™ TOB2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA564968

Catalog No. PIPA564968

Description

Immunogen sequence: PELDKEIKSSF NPDAQVFVPI GSQDSSLSNS PSPSFGQSPS PTFIPRSAQP ITFTTASFAA TKFGSTKMKK GGGAASGGGV ASSGAGGQQP PQQPRMARSP TNSLLKHKSL SLSMHSLNFI TANPAPQSQL SPNAKEFVYN GGGSPSLFFD AADGQGSGTP GPFGGSGAGT CNSS Highest antigen sequence identity to the following orthologs - mouse 86%, rat 88%.

TOB2 is a 344 amino acid rich novel member of the Tob/BTG1 anti-proliferative family of proteins characterized by similarities in their N-terminal BTG/Tob homology domains. This anti-proliferative protein inhibits cell cycle progression from the G0/G1 to S phases and is involved in cell cycle regulation through interaction with Caf1, a component of the CCR4 transcription factor complex that associates with cyclin-dependent kinases. Recent reports suggest that TOB2 plays important roles in spermatogenesis, embryonic dorsoventral patterning, osteogenesis, T-cell activation, learning and memory and acts primarily as a transcriptional repressor in several signaling pathways. TOB2, a signaling protein, may participate in transcriptional regulation of several genes. It is a regulatory protein ubiquitously expressed in most of the tissues.

Specifications

• Antigen: TOB2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Tob2
• Gene Alias: 2900090N22Rik; 4930545K18Rik; APRO5; AV071822; hypothetical protein; KIAA1663; mKIAA1663; protein Tob2; Protein Tob4; Tob2; TOB4; TOBL; Transducer of erbB-2 2; transducer of ERBB2, 2; TROB2
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 10766
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunocytochemistry
• Concentration: 0.05 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q14106
• Gene Symbols: Tob2
• Immunogen: Recombinant Human TOB2. Recombinant protein control fragment (Product #RP-105739).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov