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Invitrogen™ TOB2 Polyclonal Antibody
Rabbit Polyclonal Antibody
Supplier: Invitrogen™ PA5110504
Description
Immunogen sequence: MQLEIKVALN FIISYLYNKL PRRRADLFGE ELERLLKKKY EGHWYPEKPL KGSGFRCVHI GEMVDPVVEL.
TOB2 is a 344 amino acid rich novel member of the Tob/BTG1 anti-proliferative family of proteins characterized by similarities in their N-terminal BTG/Tob homology domains. This anti-proliferative protein inhibits cell cycle progression from the G0/G1 to S phases and is involved in cell cycle regulation through interaction with Caf1, a component of the CCR4 transcription factor complex that associates with cyclin-dependent kinases. Recent reports suggest that TOB2 plays important roles in spermatogenesis, embryonic dorsoventral patterning, osteogenesis, T-cell activation, learning and memory and acts primarily as a transcriptional repressor in several signaling pathways. TOB2, a signaling protein, may participate in transcriptional regulation of several genes. It is a regulatory protein ubiquitously expressed in most of the tissues.
Specifications
TOB2 | |
Polyclonal | |
Unconjugated | |
Tob2 | |
2900090N22Rik; 4930545K18Rik; APRO5; AV071822; hypothetical protein; KIAA1663; mKIAA1663; protein Tob2; Protein Tob4; Tob2; TOB4; TOBL; Transducer of erbB-2 2; transducer of ERBB2, 2; TROB2 | |
Rabbit | |
Affinity chromatography | |
RUO | |
10766, 315159, 57259 | |
-20°C, Avoid Freeze/Thaw Cycles | |
Liquid |
ELISA, Immunohistochemistry (Paraffin), Western Blot | |
0.11 mg/mL | |
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3 | |
Q14106, Q9JM55 | |
Tob2 | |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-70 of human TOB2 (NP_057356.1). | |
100 μL | |
Primary | |
Human, Mouse, Rat | |
Antibody | |
IgG |
Safety and Handling
WARNING: Cancer - www.P65Warnings.ca.gov
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