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Toca-1 Rabbit anti-Human, Polyclonal, Bethyl Laboratories
Rabbit Polyclonal Antibody
Supplier: Bethyl Laboratories, Inc A303469A

Description
The recommended shelf life for this product is 1 year from date of receipt. Based on 100% sequence identity, this antibody is predicted to react with Mouse and Rat
Actin reorganization is important for the regulation of neuronal morphology. A protein involved in this process, the transducer of cdc42-dependent actin assembly 1 (TOCA-1) protein, a member of the evolutionarily conserved pombe CDC15 homology (PCH) protein family, is an essential component of the Cdc42 pathway. TOCA-1 binds both N-WASP and Cdc42 and is essential for Cdc42- and PIP2-induced actin polymerization, suggesting that TOCA-1 mediates Cdc42-dependent actin nucleation by activating the N-WASP-WIP complex. Decreased expression of TOCA-1 significantly enhances neurite elongation in PC-12 cells; its overexpression in the same cells suppresses neurite elongation. It has been suggested that TOCA-1 negatively regulates axon branching by regulating membrane trafficking by regulating membrane trafficking through the F-BAR/EFC domain. Multiple isoforms of TOCA-1 are known to exist.Specifications
Toca-1 | |
Polyclonal | |
Unconjugated | |
FNBP1L | |
C1orf39, TOCA1; formin-binding protein 1-like; toca-1; transducer of Cdc42-dependent actin assembly 1; transducer of Cdc42-dependent actin assembly protein 1 | |
Rabbit | |
Antigen affinity chromatography | |
RUO | |
54874 | |
4° C | |
Liquid |
Immunoprecipitation | |
1 mg/ml | |
phosphate, tris citrate with 0.09% sodium azide; pH 7-8 | |
Q5T0N5 | |
FNBP1L | |
Between 50 and 100 | |
100 μL | |
Primary | |
Human | |
Antibody | |
IgG |
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