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Invitrogen™ Tocilizumab Chimeric Recombinant Rabbit Monoclonal Antibody (rhPM-1 (Tocilizumab))
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Catalog No. PIMA548062
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200 μg
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PIMA548062 200 μg
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Catalog No. PIMA548062 Supplier Invitrogen™ Supplier No. MA548062
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Description

Rabbit Recombinant Monoclonal Antibody

Specificity: Tocilizumab binds specifically to both the membrane bound and soluble forms of human IL-6R. The IL6 receptor is a protein complex consisting of an IL-6 receptor subunit (IL6R) and interleukin 6 signal transducer Glycoprotein 130. Interleukin 6 (IL6) is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in immune response.

Tocilizumab (Actemra) is a humanized monoclonal antibody that is developed by Hoffmann-La Roche and Chugai for the treatment of patients with rheumatoid arthritis (RA) and systemic juvenile idiopathic arthritis, a severe form of arthritis in children. Tocilizumab binds to the interleukin-6 receptor (IL-6R) and blocks its interaction with interleukin 6 (IL-6), hindering IL-6 from exerting its pro-inflammatory effects.
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Specifications

Antigen Tocilizumab Chimeric
Applications ELISA, Inhibition Assays, Immunocytochemistry
Classification Recombinant Monoclonal
Clone rhPM-1 (Tocilizumab)
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% ProClin 300
Gene Alias Actemra; Atlizumab; MRA; R-1569; RHPM-1; RO-4877533
Host Species Rabbit
Immunogen This antibody was prepared by CDR grafting of mouse PM-1 antibody onto a human framework regions.
Purification Method Protein A
Quantity 200 μg
Regulatory Status RUO
Primary or Secondary Primary
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG κ
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