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Tocris Bioscience™ Tolcapone
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Catalog No. 586410
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586410 10 mg
586450 50 mg
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Catalog No. 586410 Supplier Tocris Bioscience™ Supplier No. 5864/10
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Description

COMT inhibitor; also inhibits transthyretin aggregation

Tolcapone is a COMT inhibitor. Inhibits both brain and peripheral COMT. Also binds transthyretin (TTR) with high affinity (Kd1 and Kd2 values are 21 and 58 nM, respectively). Inhibits TTR aggregation in human plasma and prevents TTR-induced cytotoxicity in vitro. Stabilizes TTR in mice and humans in vivo. Orally bioavailable.

Specifications

Chemical Name or Material (3,4-Dihydroxy-5-nitrophenyl)(4-methylphenyl)methanone
CAS 134308-13-7
Synonym Tasmar, Ro 40-7592
Quantity 10 mg
Target Catechol O-Methyltransferase (COMT) Inhibitors
Molecular Formula C14H11NO5
Formula Weight 273.24
Purity >99%
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