Tolfenamic Acid, 99+%, PROMO, Thermo Scientific Chemicals

Description

NSAID that activates calcium-activated potassium channels

Applications

Tolfenamic acid is a non-steroidal anti-inflammatory agent. It interferes with synthesis of B-amyloid precursor protein, and thus AB peptides, by promoting degradation of an essential transcription factor. It inhibits fMLP- and A23187-induced Ca²⁺ influx in human PMNL with an IC50 value of approximately 20 μM.

Solubility

Soluble in water (slightly), acetone (approx.10 mg/mL), DMSO (52 mg/mL at 25°C), methanol (approx.10 mg/mL) and ethanol (50 mg/mL).

Notes

Stable under recommended storage conditions. Incompatible with oxidizing agents.

Specifications

Chemical Identifiers

• CAS: 13710-19-5
• Molecular Formula: C14H12ClNO2
• Molecular Weight (g/mol): 261.71 g/mol
• MDL Number: MFCD00133865
• InChI Key: YEZNLOUZAIOMLT-UHFFFAOYSA-N
• Synonym: tolfenamic acid, clotam, n-3-chloro-2-methylphenyl anthranilic acid, 2-3-chloro-2-methylphenyl amino benzoic acid, tolfedine, acido tolfenamico, acide tolfenamique, acidum tolfenamicum, tolfine, n-2-methyl-3-chlorophenyl anthranilic acid
• PubChem CID: 610479
• ChEBI: CHEBI:32243
• IUPAC Name: 2-(3-chloro-2-methylanilino)benzoic acid
• SMILES: CC1=C(C=CC=C1Cl)NC2=CC=CC=C2C(=O)O

• Color: White
• Quantity: 10 g
• UN Number: UN2811
• Merck Index: 14,9513
• Solubility Information: Soluble in water, acetone, DMSO, methanol and ethanol.
• Percent Purity: ≥99%
• Physical Form: Crystalline Powder
• Chemical Name or Material: Tolfenamic acid

Safety and Handling

DOTInformation	Transport Hazard Class: 6.1; Packing Group: III; Proper Shipping Name: TOXIC SOLIDS, ORGANIC, N.O.S.
EINECSNumber	237-264-3
RTECSNumber	CB2687500
TSCA	No

RUO - Research Use Only