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Invitrogen™ TOLLIP Polyclonal Antibody
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Catalog No. PIPA530747
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100 μL
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Catalog No. Quantity
PIPA530747 100 μL
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Catalog No. PIPA530747 Supplier Invitrogen™ Supplier No. PA530747
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Description

Rabbit Polyclonal Antibody

Recommended positive controls: NT2D1, IMR32, U87-MG, MCF-7, CL1-5. Predicted reactivity: Mouse (90%), Rat (90%), Pig (88%), Chicken (87%), Rhesus Monkey (100%), Bovine (89%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Toll-like receptors (TLRs) are evolutionarily conserved pattern-recognition molecules resembling the toll proteins that mediate antimicrobial responses in Drosophila. These proteins recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. The TLRs act through adaptor molecules to activate various kinases and transcription factors so the organism can respond to potential infection. These adaptor molecules include TOLLIP, MyD88, and TRIF. TOLLIP associates directly with TLR2 and TLR 4, acting as an inhibitor to TLR activation. This negative regulation of TLR signaling may serve to limit the production of proinflammatory mediators during infection and inflammation.
TRUSTED_SUSTAINABILITY

Specifications

Antigen TOLLIP
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 0.63 mg/mL
Conjugate Unconjugated
Formulation 0.1M tris glycine with 20% glycerol and 0.01% thimerosal; pH 7
Gene TOLLIP
Gene Accession No. Q9H0E2, Q9QZ06
Gene Alias 4930403G24Rik; 4931428G15Rik; adapter protein; EMBL:AAI33068.1}; FLJ33531; IL-1RAcPIP; toll interacting protein; toll-interacting protein; TOLLIP; tollip {ECO:0000312
Gene Symbols TOLLIP
Host Species Rabbit
Immunogen Recombinant protein encompassing a sequence within the center region of human Tollip. The exact sequence is proprietary.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 54472, 54473
Target Species Human, Mouse
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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