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Invitrogen™ TOM70 Polyclonal Antibody
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Catalog No. PIPA592197
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100 μL
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PIPA592197 100 μL
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Catalog No. PIPA592197 Supplier Invitrogen™ Supplier No. PA592197
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: KNREPLMPSP QFIKSYFSSF TDDIISQPML KGEKSDEDKD KEGEALEVKE NSGYLKAKQY MEEENYDKII SECSKEIDAE GKYMAEALLL RATFYLLIGN ANAAKPDLDK VISLKEANVK LRANALIKRG SMYMQQQQPL LSTQDFNMAA DIDPQNADVY HHRGQLKILL DQVEEAVADF DECIRLRPES ALAQAQKCFA LYRQAYTGNN SSQIQAAMKG FEEVIKKFPR CAEGYALYAQ ALTDQQQFGK ADEMYDKCID LEPDNATTYV HKGLLQLQWK QDLDRGLELI SKAIEIDNKC DFAYETMGTI EVQRGNMEKA IDMFNKAINL AKSEMEMAHL YSLCDAAHAQ TEVAKKYGLK PPTL Positive Samples: Mouse liver, Rat brain, Rat liver; Cellular Location: Mitochondrion outer membrane, Single-pass membrane protein.

Functional mitochondria require up to 1000 proteins to function properly, with 99% synthesized as precursors in the cytoplasm and transported into the mitochondria with the aid of cytosolic chaperones and mitochondrial translocators (import components). Proteins to be imported are chaperoned to the mitochondria by the cytosolic heat shock protein (cHSP70) and are immediately pursued by Translocators of the Outer Membrane (TOMs), followed by transient interactions of the unfolded proteins with Translocators of the Inner Membrane (TIMs). TOMM70A is ubiquitously expressed in human tissues and localizes in the mitochondria. TOMM70A could play a significant role in the import of nuclear-encoded mitochondrial proteins with internal targeting sites such as ADP/ATP carriers and the uncoupling proteins.
TRUSTED_SUSTAINABILITY

Specifications

Antigen TOM70
Applications ELISA, Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 0.37 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.05% ProClin 300; pH 7.3
Gene TOMM70
Gene Accession No. O94826, Q75Q39, Q9CZW5
Gene Alias 2610044B22Rik; D16Ium22; D16Ium22e; D16Wsu109e; FLJ90470; KIAA0719; Mitochondrial import receptor subunit TOM70; mitochondrial precursor proteins import receptor; mKIAA0719; Tom70; Tomm70; Tomm70a; Translocase of outer membrane 70 kDa subunit; translocase of outer mitochondrial membrane 70; translocase of outer mitochondrial membrane 70 homolog A; translocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae); translocase of outer mitochondrial membrane 70 homolog A (yeast); translocase of outer mitochondrial membrane protein 70
Gene Symbols TOMM70, Tomm70a
Host Species Rabbit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 245-608 of human TOM70 (NP_0556353).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 28185, 304017, 9868
Target Species Human, Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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