TOP2A (phospho S1106) Rabbit anti-Human, Mouse, Polyclonal , Abnova
Rabbit polyclonal antibody raised against synthetic phosphopeptide of human TOP2A.
Manufacturer: Abnova Corporation PAB29634
This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, alpha, is localized to chromsome 17 and the beta gene is localized to chromosome 3. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia. [provided by RefSeq]
|TOP2A (phospho S1106)|
|Immunohistochemistry (1:50-1:100) Western Blot (1:500-1:3000) The optimal working dilution should be determined by the end user.|
|Synthetic phosphopeptide (conjugated with KLH) corresponding to residues surrounding S1106 of human TOP2A.|
|Store at -20°C.
Aliquot to avoid repeated freezing and thawing.
|TOP2A (phospho S1106) polyclonal antibody detects endogenous levels of human TOP2A only when phosphorylated at serine 1106.|
|Immunohistochemistry (PFA fixed), Western Blot|
|Rabbit polyclonal antibody raised against synthetic phosphopeptide of human TOP2A.|
|In PBS (without Mg2+ and Ca2+), 150 mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide)|