Invitrogen™ TOP2B Polyclonal Antibody

Catalog No.	Quantity
PIPA5111315	100 μL

Catalog No. PIPA5111315 Supplier Invitrogen™ Supplier No. PA5111315

Description

Rabbit Polyclonal Antibody

Immunogen sequence: DKVPSKTVAA KKGKPSSDTV PKPKRAPKQK KVVEAVNSDS DSEFGIPKKT TTPKGKGRGA KKRKASGSEN EGDYNPGRKT SKTTSKKPKK TSFDQDSDVD IFPSDFPTEP PSLPRTGRAR KEVKYFAESD EEEDDVDF Highest antigen sequence indentity to the following orthologs: Mouse - 91%, Rat - 29%.

TOP2B (DNA Topoisomerase II Beta) is a Protein Coding gene. This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, beta, is localized to chromosome 3 and the alpha form is localized to chromosome 17. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia. Alternative splicing results in multiple transcript variants.

Specifications

• Antigen: TOP2B
• Applications: Western Blot
• Classification: Polyclonal
• Concentration: 0.1 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene: TOP2B
• Gene Accession No.: Q02880
• Gene Alias: antigen MLAA-44; D230016L12Rik; DNA topoisomerase 2-beta; DNA topoisomerase II beta; DNA topoisomerase II, 180 kD; DNA topoisomerase II, beta isozyme; Top-2; Top2b; top2beta; TOPIIB; topo II beta; topoisomerase (DNA) II beta; topoisomerase (DNA) II beta 180kDa; topoisomerase II beta; topoisomerase IIb; U937 associated antigen
• Gene Symbols: TOP2B
• Host Species: Rabbit
• Immunogen: Recombinant Protein corresonding to Human TOP2B. Recombinant protein control fragment (Product #RP-104901).
• Purification Method: Antigen affinity chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 7155
• Target Species: Human
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG