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Invitrogen™ TOP3A Polyclonal Antibody, Invitrogen™
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Catalog No. PIPA5121538
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PIPA5121538 100 μL
PIPA5121539 20 μL
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Catalog No. PIPA5121538 Supplier Invitrogen™ Supplier No. PA5121538
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Description

Rabbit Polyclonal Antibody

DNA topoisomerases are nuclear enzymes that regulate the topological structure of DNA by transiently breaking and rejoining DNA strands. Although DNA topoisomerase I (Topo I) and Topo II relax both positive and negative supercoils, Topo III relaxes only negative supercoils. Topo IIIalpha exists as a long and a short isoform, which are produced by alternative splicing. Topo IIIalpha, which localizes to the nucleolus, is constitutively expressed and remains at high levels throughout the cell cycle in HL-60 cells. Topo IIIbeta exists as three isoforms,beta-1,beta -2 and beta-3, also produced by alternative splicing. Topo IIIbeta-1 is expressed in testis, heart, and skeletal muscle, whereas Topo IIIbeta-2 is expressed in thymus, kidney and pancreas.
TRUSTED_SUSTAINABILITY

Specifications

Antigen TOP3A
Applications Immunohistochemistry (Paraffin)
Classification Polyclonal
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.05% ProClin 300; pH 7.4
Gene Top3a
Gene Accession No. Q13472
Gene Alias DNA topoisomerase 3-alpha; DNA topoisomerase III alpha; Top IIIa; TOP3; TOP3A; topo III-alpha; topoisomerase (DNA) 3 alpha; topoisomerase (DNA) III alpha; topoisomerase 3 alpha; ZGRF7; zinc finger, GRF-type containing 7
Gene Symbols Top3a
Host Species Rabbit
Immunogen Lys35-Ser179 (Accession Q13472), with N-terminal His Tag.
Purification Method Antigen affinity chromatography, Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 7156
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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