TOP3A Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Catalog No.	Quantity
50-172-9515	150 μL

Catalog No. 50-172-9515 Supplier Proteintech Group Inc Supplier No. 145251AP150UL

Description

Rabbit Polyclonal Antibody

This antibody is specific to react with the 110 kDa human TOP3A.

DNA topoisomerases are nuclear enzymes that regulate the topological structure of DNA by transiently breaking and rejoining DNA strands. Although DNA topoisomerase I (Topo I) and Topo II relax both positive and negative supercoils, Topo III relaxes only negative supercoils. Topo IIIalpha exists as a long and a short isoform, which are produced by alternative splicing. Topo IIIalpha, which localizes to the nucleolus, is constitutively expressed and remains at high levels throughout the cell cycle in HL-60 cells. Topo IIIbeta exists as three isoforms,beta-1,beta -2 and beta-3, also produced by alternative splicing. Topo IIIbeta-1 is expressed in testis, heart, and skeletal muscle, whereas Topo IIIbeta-2 is expressed in thymus, kidney and pancreas.

Specifications

• Antigen: TOP3A
• Applications: Immunoprecipitation, Western Blot
• Classification: Polyclonal
• Concentration: 0.43 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene: TOP3A
• Gene Accession No.: O70157, Q13472
• Gene Alias: DNA topoisomerase 3 alpha, DNA topoisomerase III alpha, TOP3, TOP3A, topoisomerase (DNA) III alpha
• Gene Symbols: TOP3A
• Host Species: Rabbit
• Immunogen: TOP3A Fusion Protein Ag6010
• Purification Method: Antigen Affinity Chromatography
• Quantity: 150 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 21975, 303194, 7156
• Target Species: Human, Mouse, Rat
• Content And Storage: -20°C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG