Invitrogen™ TOPORS Monoclonal Antibody (4G4)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA520967

Catalog No. PIMA520967

Description

Peptide Sequence: SPDSKCPICL DRFDNVSYLD RCLHKFCFRC VQEWSKNKAE CPLCKQPFDS IFHSVRAEDD FKEYVLRPSY NGSFVTPDRR FRYRTTLTRE RNASVYSPSG PVNRRTTT.

Functions as an E3 ubiquitin-protein ligase and as an E3 SUMO1-protein ligase. Probable tumor suppressor involved in cell growth, cell proliferation and apoptosis that regulates p53/TP53 stability through ubiquitin-dependent degradation. May regulate chromatin modification through sumoylation of several chromatin modification-associated proteins. May be involved in DNA damage-induced cell death through IKBKE sumoylation.

Specifications

• Antigen: TOPORS
• Classification: Monoclonal
• Concentration: 0.5 mg/mL
• Formulation: PBS with no preservative; pH 7.4
• Gene Accession No.: Q9NS56
• Gene Symbols: TOPORS
• Immunogen: TOPORS (NP_005793, 98 a.a. ~ 205 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG2a κ

• Applications: ELISA, Western Blot, Immunocytochemistry
• Clone: 4G4
• Conjugate: Unconjugated
• Gene: TOPORS
• Gene Alias: AW105885; E3 ubiquitin-protein ligase Topors; LUN; p53-binding protein 3; P53BP3; p53BP3/LUN; RING-type E3 ubiquitin transferase Topors; RP31; SUMO1-protein E3 ligase Topors; TOP1 binding arginine/serine rich protein; topoisomerase 1-binding RING finger; topoisomerase I binding, arginine/serine-rich; topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase; topoisomerase I-binding arginine/serine-rich protein; Topoisomerase I-binding RING finger protein; Topors; TP53BPL; tumor suppressor p53-binding protein 3
• Host Species: Mouse
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 10210
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid