TORC1 Rabbit anti-Human, Mouse, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Supplier:  Proteintech Group Inc 104411AP150UL

Catalog No. 50-172-6311

Description

This is a rabbit polyclonal antibody raised against residues near the N terminus of human CRTC1.

Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 ′Ser-133′ phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, Star. Potent coactivator of PGC1alpha and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR). In the hippocampus, involved in late-phase long-term potentiation (L-LTP) maintece at the Schaffer collateral-CA1 synapses. May be required for dendritic growth of developing cortical neurons.

Specifications

• Antigen: TORC1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: CRTC1
• Gene Alias: CRTC1, KIAA0616, MECT1, mTORC1, TORC 1, TORC1, Transducer of CREB protein 1, WAMTP1
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 23373, 382056
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunoprecipitation, Western Blot
• Concentration: 0.2 mg/mL
• Formulation: PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
• Gene Accession No.: Q68ED7, Q6UUV9
• Gene Symbols: Crtc1
• Immunogen: TORC1 Fusion Protein Ag0693
• Quantity: 150 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG