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Tocris Bioscience™ Torin 1
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Catalog No. 424710
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42-471-0 10 mg
42-475-0 50 mg
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Description

Potent and selective mTOR inhibitor

Torin 1 is a potent and selective ATP-competitive mTOR inhibitor (IC50 = 2 - 10 nM for mTORC1 and mTORC2). Torin 1 displays 200-fold selectivity for mTOR over DNA-PK, ATM and hVps34. In HeLa cells, Torin 1 induces autophagy. Torin 1 impairs cell growth and proliferation by suppression of the rapamycin-resistant functions of mTORC1. In human monocytes and myeloid dendritic cells, Torin 1 prevents decreases the anti-inflammatory potency of glucocorticoids. In the human endocrine cell line BON, Torin 1 increases neurotensin secretion and gene expression through MEK/ERK/c-Jun pathway activation.

Chemical Identifiers

CAS 1222998-36-8
Molecular Formula C35H28F3N5O2

Specifications

Quantity 10 mg
Formula Weight 607.62
Purity >98%
Molecular Weight (g/mol) 607.64
Chemical Name or Material Torin 1

Safety and Handling

Recommended Storage Store at +4°C
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