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  5. Tocris Bioscience™ TP 064

Tocris Bioscience™ TP 064
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Catalog No. 600810
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Catalog No. Quantity
60-081-0 10 mg
60-085-0 50 mg
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Catalog No. 60-081-0 Supplier Tocris Bioscience™ Supplier No. 6008/10
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Description

Potent and selective PRMT 4 inhibitor

TP 064 is a potent and selective PRMT4 inhibitor; inhibits methylation of H3 (1-25) and MED12 (IC50 values are <10 and 43 nM, respectively). Exhibits >100-fold selectivity over other histone methyltransferases and non-epigenetic targets. Inhibits proliferation of certain multiple myeloma cell lines, arresting cells in G1 phase. TP 064 can be used in vivo. TP 064 inhibits the monocyte/macrophage-driven inflammation in ex vivo.

To request the negative control for TP 064, please fill out the TP 064N request form on the SGC website..

Specifications

Chemical Name or Material TP 064
Synonym N-Methyl-N-((2-(1-(2-(methylamino)ethyl)piperidin-4-yl)pyridin-4-yl)methyl)-3-phenoxybenzamide
Quantity 10 mg
Solubility Soluble to 100mM in 1eq. HCl and to 100mM in DMSO
Molecular Formula C28H34N4O2
Formula Weight 458.6
Physical Form Solid
Color White
Product Type Bioactive Small Molecule
Purity >98%

For Research Use Only.

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