TP53BP1 Mouse anti-Human, Clone: OTI5H4, lyophilized, TrueMAB™

Mouse Monoclonal Antibody

Supplier:  OriGene CF806952

Catalog No. 50-166-8049

Description

Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCO

53BP1 (P53-binding protein 1) plays a critical role in tumor suppression and is a putative substrate of ATM kinase. Upon DNA damage, 53BP1 is phosphorylated and localizes to the presumptive sites of damage, specifically, double-strand breaks. 53BP1 may have a role in checkpoint signaling during mitosis, enhances TP53-mediated transcriptional activation, and participates in DNA repair by maintaining genomic stability.

Specifications

• Antigen: TP53BP1
• Classification: Monoclonal
• Conjugate: Unconjugated
• Gene: TP53BP1
• Gene Alias: 53BP1, TDRD30, TP53, p202, p53BP1
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 7158
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Lyophilized

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Clone: OTI5H4
• Formulation: PBS with 8% trehalose and no preservative; pH 7.3
• Gene Accession No.: Q12888
• Gene Symbols: TP53BP1
• Immunogen: Human recombit protein fragment corresponding to amino acids 1-300 of human TP53BP1 produced in E.coli.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1