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TPCN2 (extracellular) Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Supplier:  Thermo Scientific PA577336

Catalog No. PIPA577336


Description

Description

Product is shipped at room temperature as a lyophilized powder and should be stored at -20 °C upon receipt. Reconstitution: add 50 μL of deionized water.

Tpcn2 is a nicotinic acid adenine dinucleotide phosphate (NAADP) receptor that may function as one of the major voltage-gated Ca(2+) channels (VDCC) across the lysosomal membrane. Tpcn2 may also be involved in smooth muscle contraction. The Tpcn2 gene encodes a putative cation-selective ion channel with two repeats of a six-transmembrane-domain. The Tpcn2 protein localizes to lysosomal membranes and enables nicotinic acid adenine dinucleotide phosphate (NAADP) -induced calcium ion release from lysosome-related stores. Tpcn2 is a ubiquitously expressed gene that has elevated expression in liver and kidney. Two common nonsynonymous SNPs in the Tpcn2 gene strongly associate with blond versus brown hair pigmentation. Diseases associated with TPCN2 include Deafness, Autosomal Recessive 63 and Deafness, Autosomal Recessive 7.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

TPCN2 (extracellular)
Polyclonal
Unconjugated
TPCN2
TPCN2, TPC2
Rabbit
Antigen affinity chromatography
RUO
219931, 233979, 309139
-20°C
Lyophilized
Immunofluorescence, Immunohistochemistry (Frozen), Western Blot
0.85 mg/mL
PBS with 1% BSA and 0.05% sodium azide; pH 7.4
Q8BWC0, Q8NHX9
Tpcn2
Peptide KKTLKSIRW(S)LPE(C), corresponding to amino acid residues 187-199 of mouse Two pore calcium channel protein 2 with replacement of amino acid 192 with serine (S)
50 μL
Primary
Human, Mouse, Rat
Antibody
IgG
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