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Invitrogen™ TPCN2 Polyclonal Antibody
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Catalog No. PIPA555498
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100 μL
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PIPA555498 100 μL
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Catalog No. PIPA555498 Supplier Invitrogen™ Supplier No. PA555498
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: QFRGYLMKSL QTSLFRRRLG TRAAFEVLSS MVGEGGAFPQ AVGVKPQNLL QVLQKVQLDS SHRQAMMEKV RSYGSVLLSA EEFQKLFNEL DRSVVKEHPP RPEYQSPFLQ SAQFLFGHYY F Highest antigen sequence identity to the following orthologs: Mouse - 63%, Rat - 63%.

Tpcn2 is a nicotinic acid adenine dinucleotide phosphate (NAADP) receptor that may function as one of the major voltage-gated Ca(2+) channels (VDCC) across the lysosomal membrane. Tpcn2 may also be involved in smooth muscle contraction. The Tpcn2 gene encodes a putative cation-selective ion channel with two repeats of a six-transmembrane-domain. The Tpcn2 protein localizes to lysosomal membranes and enables nicotinic acid adenine dinucleotide phosphate (NAADP) -induced calcium ion release from lysosome-related stores. Tpcn2 is a ubiquitously expressed gene that has elevated expression in liver and kidney. Two common nonsynonymous SNPs in the Tpcn2 gene strongly associate with blond versus brown hair pigmentation. Diseases associated with TPCN2 include Deafness, Autosomal Recessive 63 and Deafness, Autosomal Recessive 7.
TRUSTED_SUSTAINABILITY

Specifications

Antigen TPCN2
Applications Immunohistochemistry (Paraffin)
Classification Polyclonal
Concentration 0.1 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene TPCN2
Gene Accession No. Q8NHX9
Gene Alias BC025890; D830047E22Rik; SHEP10; Tpc2; TPCN2; Two pore calcium channel protein 2; two pore segment channel 2; two-pore calcium channel protein 2; voltage-dependent calcium channel protein TPC2
Gene Symbols TPCN2
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human TPCN2. Recombinant protein control fragment (Product #RP-91224).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 219931
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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