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Invitrogen™ TPL2 Recombinant Rabbit Monoclonal Antibody (HL2118)
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Catalog No. FEMA550385
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100 μL
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FEMA550385 100 μL
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Catalog No. FEMA550385 Supplier Invitrogen™ Supplier No. MA550385
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Description

Rabbit Recombinant Monoclonal Antibody

TPL2 Recombinant Monoclonal Antibody for Western Blot, IHC (P)

MAP3K8 (COT) is a serine/threonine kinase which can activate both the MAP and JNK kinase pathways and plays a role in the cell cycle. Mitogen-activated protein kinase (MAPK) signaling cascades include MAPK or extracellular signal-regulated kinase (ERK), MAPK kinase (MKK or MEK), and MAPK kinase (MAPKKK or MEKK). MAPKK kinase/MEKK phosphorylates and activates its downstream protein kinase, MAPK kinase/MEK, which in turn activates MAPK. The kinases of these signaling cascades are highly conserved, and homologs exist in yeast, Drosophila, and mammalian cells. MEKK8 is able to activate NF-kappa-B 1 by stimulating proteasome-mediated proteolysis of NF-kappa-B 1/p105. This cytoplasmic protein is expressed in several normal tissues and human tumor-derived cell lines. The 58 kDa form is activated specifically during the S and G2/M phases of the cell cycle. The longer form undergoes phosphorylation on Ser residues mainly, and the shorter form on both Ser and Thr residues.
TRUSTED_SUSTAINABILITY

Specifications

Antigen TPL2
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Recombinant Monoclonal
Clone HL2118
Concentration 2 mg/mL
Conjugate Unconjugated
Formulation PBS with no preservative
Gene MAP3K8
Gene Accession No. P41279, Q07174
Gene Alias augmented in rheumatoid arthritis 2; AURA2; Cancer Osaka thyroid oncogene; cancer Osaka thyroid, oncogene; CCOT; c-COT; COT; cot (cancer Osaka thyroid) oncogene; COT proto-oncogene serine/threonine-protein kinase; Cot/Tpl2; D17TPL2; EC 1.14.16.2; Est; Estf; Ewing sarcoma transformant; FLJ10486; M3K8; MAP3K 8; Map3k8; MEKK8; mitogen activated protein kinase kinase kinase 8; mitogen-activated protein kinase kinase kinase 8; Protein kinase cot; Proto-oncogene c-Cot; proto-oncogene serine/threoine protein kinase; serine/threonine kinase (Tpl-2); serine/threonine-protein kinase cot; TH isoform 3; TH isoform a; TH-4; TPL 2; Tpl2; TPL-2; Tumor progression locus 2; TY3H; TYH
Gene Symbols MAP3K8
Host Species Rabbit
Immunogen Recombinant fragmemt of human MAP3K8.
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 1326, 26410
Target Species Human, Mouse
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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