Invitrogen™ TPM2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA591925

Catalog No. PIPA591925

Description

Positive Samples: SW620, HeLa, MCF7, U-87MG, Mouse skeletal muscle, Mouse lung; Cellular Location: Cytoplasm, cytoskeleton Immunogen sequence: MDAIKKKMQM LKLDKENAID RAEQAEADKK QAEDRCKQLE EEQQALQKKL KGTEDEVEKY SESVKEAQEK LEQAEKKATD AEADVASLNR RIQLVEEELD.

TPM2 (tropomyosin 2) is beta-tropomyosin, an isoform of tropomyosin that is mainly expressed in slow, type 1 muscle fibers. TPM2 binds to actin filaments in muscle and non-muscle cells. Plays a central role in association with the troponin complex in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. Mutations in this gene can cause nemaline myopathy 4, arthrogryposis dital 1A/2B, and cap myopathy 2.

Specifications

• Antigen: TPM2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: TPM2
• Gene Alias: AMCD1; beta tropomyosin; beta-tropomyosin; cb836; cytoskeletal protein; DA1; DA2B; epididymis secretory protein Li 273; fj63f03; HEL-S-273; NEM4; nemaline myopathy type 4; RP11-112J3.4; TMSB; TPM2; Tpm-2; tpm4l; Trop-2; tropomyosin; tropomyosin 2; tropomyosin 2 (beta); tropomyosin 2, beta; tropomyosin beta chain; Tropomyosin-2; unnamed protein product; wu:fj63f03; zgc:86810
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 22004, 500450, 7169
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot, Immunocytochemistry
• Concentration: 1.07 mg/mL
• Formulation: PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
• Gene Accession No.: P07951, P58774, P58775
• Gene Symbols: TPM2
• Immunogen: A synthetic peptide corresponding to a sequence within amino acids 1-100 of human TPM2 (NP_003280.2).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG