TPMT Monoclonal Antibody (OTI4B1), TrueMAB™, OriGene

Catalog No.	Quantity
50-167-2212	100 μL
50-254-2560	30 μL

Catalog No. 50-167-2212 Supplier OriGene Supplier No. TA501069

Description

Mouse Monoclonal Antibody

Catalyzes the S-methylation of thiopurine drugs such as 6-mercaptopurine. Defects in TPMT are the cause of thiopurine S-methyltransferase deficiency (TPMT deficiency).TPMT is an enzyme involved in the normal metabolic inactivation of thiopurine drugs. These drugs are generally used as immunosupressants or cytotoxic drugs and are prescribed for a variety of clinical conditions including leukemia, autoimmune disease and organ transplantation. Patients with intermediate or no TPMT activity are at risk of toxicity after receiving standard doses of thiopurine drugs and it is shown that inter-individual differences in response to these drugs are largely determined by genetic variation at the TPMT locus.

Specifications

• Antigen: TPMT
• Applications: Immunohistochemistry (Paraffin), Western Blot
• Classification: Monoclonal
• Clone: OTI4B1
• Concentration: 0.89 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
• Gene: TPMT
• Gene Accession No.: P51580
• Gene Alias: TPMTD
• Gene Symbols: TPMT
• Host Species: Mouse
• Immunogen: Full length human recombit protein of human TPMT produced in HEK293T cell.
• Purification Method: Affinity Chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 7172
• Target Species: Human
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG1