TPMT Monoclonal Antibody (OTI5B4), TrueMAB™, OriGene

Mouse Monoclonal Antibody

Supplier:  OriGene TA500965

Catalog No. 50-167-2106

Description

Catalyzes the S-methylation of thiopurine drugs such as 6-mercaptopurine. Defects in TPMT are the cause of thiopurine S-methyltransferase deficiency (TPMT deficiency).TPMT is an enzyme involved in the normal metabolic inactivation of thiopurine drugs. These drugs are generally used as immunosupressants or cytotoxic drugs and are prescribed for a variety of clinical conditions including leukemia, autoimmune disease and organ transplantation. Patients with intermediate or no TPMT activity are at risk of toxicity after receiving standard doses of thiopurine drugs and it is shown that inter-individual differences in response to these drugs are largely determined by genetic variation at the TPMT locus.

Specifications

• Antigen: TPMT
• Classification: Monoclonal
• Concentration: 0.6 mg/mL
• Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
• Gene Accession No.: P51580
• Gene Symbols: TPMT
• Immunogen: Full length human recombit protein of human TPMT produced in HEK293T cell.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Clone: OTI5B4
• Conjugate: Unconjugated
• Gene: TPMT
• Gene Alias: TPMTD
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 7172
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Liquid