Invitrogen™ TPMT Polyclonal Antibody

Catalog No.	Quantity
PIPA597607	100 μg

Catalog No. PIPA597607 Supplier Invitrogen™ Supplier No. PA597607

Description

Rabbit Polyclonal Antibody

TPMT Polyclonal Antibody for Western Blot, IHC (P), IP, ELISA

Catalyzes the S-methylation of thiopurine drugs such as 6-mercaptopurine. Defects in TPMT are the cause of thiopurine S-methyltransferase deficiency (TPMT deficiency). TPMT is an enzyme involved in the normal metabolic inactivation of thiopurine drugs. These drugs are generally used as immunosupressants or cytotoxic drugs and are prescribed for a variety of clinical conditions including leukemia, autoimmune disease and organ transplantation. Patients with intermediate or no TPMT activity are at risk of toxicity after receiving standard doses of thiopurine drugs and it is shown that inter-individual differences in response to these drugs are largely determined by genetic variation at the TPMT locus.

Specifications

• Antigen: TPMT
• Applications: ELISA, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
• Classification: Polyclonal
• Concentration: 2.6 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 50% glycerol and 0.03% ProClin 300; pH 7.4
• Gene: TPMT
• Gene Accession No.: P51580
• Gene Alias: AW106912; HGNC:12014; S-adenosyl-L-methionine:thiopurine S-methyltransferase; thiopurine methyltransferase; Thiopurine S-methyltransferase; TPMT; TPMTD; truncated thiopurine methyltransferase
• Gene Symbols: TPMT
• Host Species: Rabbit
• Immunogen: Recombinant Human Thiopurine S-methyltransferase protein (4-244AA).
• Purification Method: Protein G
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 7172
• Target Species: Human
• Content And Storage: -20°C or -80°C if preferred
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG

Safety and Handling

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