TPMT Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Catalog Number	Mfr. No.	Quantity
50-172-6509	Proteintech Group Inc 106821AP150UL	150 μL

Description

This antibody specifically recognizes the 34 kDa protein.

Catalyzes the S-methylation of thiopurine drugs such as 6-mercaptopurine. Defects in TPMT are the cause of thiopurine S-methyltransferase deficiency (TPMT deficiency). TPMT is an enzyme involved in the normal metabolic inactivation of thiopurine drugs. These drugs are generally used as immunosupressants or cytotoxic drugs and are prescribed for a variety of clinical conditions including leukemia, autoimmune disease and organ transplantation. Patients with intermediate or no TPMT activity are at risk of toxicity after receiving standard doses of thiopurine drugs and it is shown that inter-individual differences in response to these drugs are largely determined by genetic variation at the TPMT locus.

Specifications

• Antigen: TPMT
• Applications: Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
• Conjugate: Unconjugated
• Host Species: Rabbit
• Target Species: Human, Mouse, Rat
• Gene Accession No.: O55060, P51580, Q9Z0T0
• Gene ID (Entrez): 22017, 690050, 7172
• Immunogen: TPMT Fusion Protein Ag1074
• Primary or Secondary: Primary
• Content And Storage: -20°C
• Gene: TPMT

• Concentration: 0.15 mg/mL
• Classification: Polyclonal
• Form: Liquid
• Regulatory Status: RUO
• Formulation: PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
• Gene Alias: Thiopurine methyltransferase, thiopurine S methyltransferase, TPMT
• Gene Symbols: TPMT
• Isotype: IgG
• Purification Method: Antigen Affinity Chromatography
• Product Type: Antibody