Invitrogen™ TPPP Recombinant Rabbit Monoclonal Antibody (JE47-35)

Rabbit Recombinant Monoclonal Antibody

Supplier:  Invitrogen™ MA534851

Catalog No. PIMA534851

Description

Positive Control: Mouse brain tissue, rat brain tissue, human pancreas tissue, human uterus tissue, SHG-44.

Tubulin family members are globular proteins important in the assembly of microtubules. Microtubules are structural components that play important roles in mitosis, cytokinesis and vesicle transport. TPPP (Tubulin polymerization-promoting protein), also known as p24 and p25, is a widely expressed 219 amino acid protein found in the perinuclear region of the cytoplasm. TPPP may form dimers and functions in polymerizing tubulin into double-walled tubules, polymorphic aggregates, or stabilized blocks. TPPP overexpression prevents formation of the mitotic spindle assembly and breakdown of the nuclear envelope. TPPP is phosphorylated by TPK II and is encoded by a gene that maps to human chromosome 5, which contains 181 million base pairs and comprises nearly 6% of the human genome. May play a role in the polymerization of tubulin into microtubules, microtubule bundling and the stabilization of existing microtubules, thus maintaining the integrity of the microtubule network. May play a role in mitotic spindle assembly and nuclear envelope breakdown.

Specifications

• Antigen: TPPP
• Classification: Recombinant Monoclonal
• Concentration: 1 mg/mL
• Formulation: TBS with 0.05% BSA, 40% glycerol and 0.05% sodium azide; pH 7.4
• Gene Accession No.: O94811
• Gene Symbols: TPPP
• Immunogen: Recombinant protein within Human TPPP aa 80-185.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

• Applications: Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot
• Clone: JE47-35
• Conjugate: Unconjugated
• Gene: TPPP
• Gene Alias: 25 kDa brain-specific protein; 2900041A09Rik; AI849835; brain specific protein p25 alpha; brain-specific protein p25 alpha; glycogen synthase kinase 3 (GSK3) inhibitor p24; p24; p25; p25alpha; p25-alpha; RGD1310121; Tppp; TPPP/p25; TPPP1; tubulin polymerization promoting protein; tubulin polymerization-promoting protein
• Host Species: Rabbit
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 11076
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles, store in dark
• Form: Liquid