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Invitrogen™ TPSB2 Polyclonal Antibody
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Catalog No. PIPA547531
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100 μg
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PIPA547531 100 μg
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Catalog No. PIPA547531 Supplier Invitrogen™ Supplier No. PA547531
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Description

Goat Polyclonal Antibody

In direct ELISAs, approximately 35% cross-reactivity with recombinant human (rh) TPS-1 and rhTPS-B2 is observed and less then 10% cross-reactivity with recombinant mouse MCP-7 is observed. Reconstitute at 0.2 mg/mL in sterile PBS.

TPSB2 is a protein coding gene. Tryptases comprise a family of trypsin-like serine proteases, the peptidase family S1. Tryptases are enzymatically active only as heparin-stabilized tetramers, and they are resistant to all known endogenous proteinase inhibitors. Several tryptase genes are clustered on chromosome 16p13.3. These genes are characterized by several distinct features. They have a highly conserved 3' UTR and contain tandem repeat sequences at the 5' flank and 3' UTR which are thought to play a role in regulation of the mRNA stability. These genes have an intron immediately upstream of the initiator Met codon, which separates the site of transcription initiation from protein coding sequence. This feature is characteristic of tryptases but is unusual in other genes. The alleles of this gene exhibit an unusual amount of sequence variation, such that the alleles were once thought to represent two separate genes, beta II and beta III. Beta tryptases appear to be the main isoenzymes expressed in mast cells, whereas in basophils, alpha-tryptases predominate. Tryptases have been implicated as mediators in the pathogenesis of asthma and other allergic and inflammatory disorders.
TRUSTED_SUSTAINABILITY

Specifications

Antigen TPSB2
Applications Immunoprecipitation, Neutralization, Western Blot
Classification Polyclonal
Concentration 0.2 mg/mL
Conjugate Unconjugated
Formulation PBS with 5% trehalose and No Preservative
Gene Tpsb2
Gene Accession No. P21845
Gene Alias AV011504; EC 3.4.21; EC 3.4.21.59; mast cell protease 6; mast cell tryptase beta II; mast cell tryptase beta III; Mcp6; Mcp-6; Mcpt6; MMCP-6; rMCP-6; testicular tissue protein Li 163; TPS2; TPS2tryptase beta-2; Tpsb2; tryptase beta 2; tryptase beta 2 (gene/pseudogene); tryptase beta II; tryptase beta III; tryptase beta-2; Tryptase II; tryptase III; Tryptase-2; tryptaseB; tryptaseC; Tryptase-C
Gene Symbols Tpsb2
Host Species Goat
Immunogen Mouse myeloma cell line NS0-derived recombinant mouse Mast Cell Protease-6/Mcpt6 Ala22-Ser276.
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 17229
Target Species Mouse
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Lyophilized
Isotype IgG
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