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Invitrogen™ TPSG1 Polyclonal Antibody
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Catalog No. PIPA584456
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PIPA584456 100 μL
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Catalog No. PIPA584456 Supplier Invitrogen™ Supplier No. PA584456
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: PYSLREVKVS VVDTETCRRD YPGPGGSILQ PDMLCAR Highest antigen sequence indentity to the following orthologs: Rat - 59%, Mouse - 65%.

Tryptase gamma, also known as serine protease 31 or transmembrane tryptase, is an enzyme that in humans is encoded by the TPSG1 gene. Tryptases comprise a family of trypsin-like serine proteases, the peptidase family S1. Tryptases are enzymatically active only as heparin-stabilized tetramers, and they are resistant to all known endogenous proteinase inhibitors. Several tryptase genes are clustered on chromosome 16p13.3. There is uncertainty regarding the number of genes in this cluster. Currently four functional genes -alpha I, beta I, beta II and gamma I - have been identified. And beta I has an allelic variant named alpha II, beta II has an allelic variant beta III, also gamma I has an allelic variant gamma II. Beta tryptases appear to be the main isoenzymes expressed in mast cells; whereas in basophils, alpha-tryptases predominant. This gene differs from other members of the tryptase gene family in that it has C-terminal hydrophobic domain, which may serve as a membrane anchor. Tryptases have been implicated as mediators in the pathogenesis of asthma and other allergic and inflammatory disorders.
TRUSTED_SUSTAINABILITY

Specifications

Antigen TPSG1
Applications Immunohistochemistry (Paraffin)
Classification Polyclonal
Concentration 0.3 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene TPSG1
Gene Accession No. Q9NRR2
Gene Alias PRSS31; serine protease 31; TMT; TPSG1; Transmembrane tryptase; trpA; Tryptase gamma; Tryptase- gamma; tryptase gamma 1; Tryptase gamma heavy chain; tryptase gamma I; tryptase gamma II; Tryptase gamma light chain
Gene Symbols TPSG1
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human TPSG1. Recombinant protein control fragment (Product #RP-103375).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 25823
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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