Invitrogen™ TPSG1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA537268

Catalog No. PIPA537268

Description

This antibody detects endogenous protein at a molecular weight of 34 kDa. Purity is >95% by SDS-PAGE.

Tryptase gamma, also known as serine protease 31 or transmembrane tryptase, is an enzyme that in humans is encoded by the TPSG1 gene. Tryptases comprise a family of trypsin-like serine proteases, the peptidase family S1. Tryptases are enzymatically active only as heparin-stabilized tetramers, and they are resistant to all known endogenous proteinase inhibitors. Several tryptase genes are clustered on chromosome 16p13.3. There is uncertainty regarding the number of genes in this cluster. Currently four functional genes -alpha I, beta I, beta II and gamma I - have been identified. And beta I has an allelic variant named alpha II, beta II has an allelic variant beta III, also gamma I has an allelic variant gamma II. Beta tryptases appear to be the main isoenzymes expressed in mast cells; whereas in basophils, alpha-tryptases predominant. This gene differs from other members of the tryptase gene family in that it has C-terminal hydrophobic domain, which may serve as a membrane anchor. Tryptases have been implicated as mediators in the pathogenesis of asthma and other allergic and inflammatory disorders.

Specifications

• Antigen: TPSG1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: TPSG1
• Gene Alias: PRSS31; serine protease 31; TMT; TPSG1; Transmembrane tryptase; trpA; Tryptase gamma; Tryptase- gamma; tryptase gamma 1; Tryptase gamma heavy chain; tryptase gamma I; tryptase gamma II; Tryptase gamma light chain
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 25823, 26945, 302990
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q9NRR2, Q9QUL7
• Gene Symbols: TPSG1
• Immunogen: A synthetic peptide corresponding to residues in human TPSG1.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG