Invitrogen™ TPT1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5120916

Catalog No. PIPA5120916

Description

Positive test controls include: SW480, MCF7, K-562, THP-1, U-251MG, 293T, HepG2, Mouse kidney. The target is usually found in the following locations: Cytoplasm. Immunogen sequence: MIIYRDLISH DEMFSDIYKI REIADGLCLE VEGKMVSRTE GNIDDSLIGG NASAEGPEGE GTESTVITGV DIVMNHHLQE TSFTKEAYKK YIKDYMKSIK GKLEEQRPER VKPFMTGAAE QIKHILANFK NYQFFIGENM NPDGMVALLD YREDGVTPYM IFFKDGLEME KC.

TPT1 (translationally controlled tumor protein 1) is a 23 kDa member of the TCTP family of calcium binding proteins. TPT1 is localized in the cytoplasm and widely expressed and serves as a transcriptional activator, calcium transporter, histamine inducer and antiapoptotic caspase 3 inhibitor. TPT1 is a cytokine-like molecule that causes the release of histamine, IL-4 and IL-13 from basophils as well as the secretion of IL-8 and a calcium response in eosinophils. TPT1 plays a pivotal role in allergic diseases and due to its wide distribution in brain, is thought to be involved in neurodegenerative disorders, such as Alzheimer's disease and Down syndrome.

Specifications

• Antigen: TPT1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: TPT1
• Gene Alias: 21 kDa polypeptide; 21 kDa polypeptide under translational control; fortilin; Histamine-releasing factor; HRF; Lens epithelial protein; p02; p21; p23; TCTP; Tpt1; translationally regulated transcript (21 kDa); translationally-controlled tumor protein; Trt; tumor protein, translationally-controlled 1
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 116646, 22070, 7178
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot
• Concentration: 1.03 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: P13693, P63028, P63029
• Gene Symbols: TPT1
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-172 of human TCTP/TCTP/TPT1 (NP_0032861).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG