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Invitrogen™ TRA-1-60 (Podocalyxin) Monoclonal Antibody (TRA-1-60), eBioscience™, Invitrogen™
Mouse Monoclonal Antibody
Supplier: Invitrogen™ 14886337
Description
The TRA-1-60 antibody recognizes a protein expressed on undifferentiated human embryonic stem cells (ES), embyronal carcinoma cells (EC), and embryonic germ cells (EG). Like other stem cell specific markers, the epitope recognized by the TRA-1-60 antibody is lost upon cell differentiation. Contrary to early reports that the TRA-1-60 epitope can be destroyed by neuraminidase digestion, new strudies have shown that TRA-1-60 recognizes a neurominidase resistent antigen. The TRA-1-60 antibody is known to specifically recognize a carbohydrate epitope on a keratan sulfated glycoprotein recently identified as podocalyxin, a member of the CD34-related family of sialomucins. Podocalyxin is a transmembrane glycoprotein originally identified on epithelial glomerular cells known as podocytes, and the protein has also been implicated in the development of aggressiveness in a variety of cancers, including breast and prostate cancer.
TRA-1-60 is a cell surface antigen, expressed along with SSEA-3, SSEA-4 and TRA-1-81 in human embryonic stem cells, embryonal carcinoma cells and induced pluripotent stem cells (iPS). These surface markers are lost during the differentiation process. In contrast, SSEA-1 is absent in undifferentiated human stem cells but is present on the cell surface after retinoic acid mediated differentiation.
Specifications
| TRA-1-60 (Podocalyxin) | |
| Monoclonal | |
| 0.5 mg/mL | |
| PBS with 0.09% sodium azide; pH 7.2 | |
| Mouse | |
| 2 mg | |
| Primary | |
| 4°C | |
| Liquid |
| Flow Cytometry, Immunohistochemistry, Immunoprecipitation, Western Blot | |
| TRA-1-60 | |
| Unconjugated | |
| TRA160; tra60 | |
| Affinity chromatography | |
| RUO | |
| Human | |
| Antibody | |
| IgM |
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