Invitrogen™ TRAC-1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5106658

Catalog No. PIPA5106658

Description

Antibody detects endogenous levels of total RNF125.

TRAC-1 is a 232 amino acid protein containing an N-terminal RING-type zinc finger domain. It functions as a positive regulator in the T-cell receptor signaling pathway, thus leading to T-cell activation. It mediates ubiquitination and subsequent proteasomal degradation of target proteins. TRAC-1 is expressed in lymphoid tissues, including bone marrow, spleen, thymus as well as in other tissues. It is predominantly expressed in the CD4+ and CD8+ T-cells, suggesting that it is preferentially confined to T-cells.

Specifications

• Antigen: TRAC-1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: RNF125
• Gene Alias: 4930553F04Rik; E3 ubiquitin-protein ligase RNF125; RING finger protein 125; ring finger protein 125, E3 ubiquitin protein ligase; RNF125; T-cell RING activation protein 1; T-cell ring protein identified in activation screen; TNORS; TRAC1; TRAC-1
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 361296, 54941, 67664
• Content And Storage: -20°C
• Form: Liquid

• Applications: Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: Q96EQ8, Q9D9R0
• Gene Symbols: RNF125
• Immunogen: A synthesized peptide derived from human RNF125(Accession Q96EQ8), corresponding to amino acid residues R138-L188.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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