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TRACP/PAP/ACP5 Antibody (rACP5/1070), Alexa Fluor™ 750, Novus Biologicals™
SDP

Catalog No. NB009164 Shop All R&D Systems Products
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NB009164 0.1 mL
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Catalog No. NB009164 Supplier Novus Biologicals Supplier No. NBP275780AF750
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Description

Mouse Monoclonal Antibody

TRACP/PAP/ACP5 Monoclonal specifically detects TRACP/PAP/ACP5 in Human, Mouse, Rat samples. It is validated for Immunohistochemistry, Immunohistochemistry-Paraffin.

Specifications

Antigen TRACP/PAP/ACP5
Applications Immunohistochemistry, Immunohistochemistry (Paraffin)
Classification Monoclonal
Clone rACP5/1070
Conjugate Alexa Fluor 750
Dilution Immunohistochemistry, Immunohistochemistry-Paraffin
Formulation 50mM Sodium Borate with 0.05% Sodium Azide
Gene Alias HPAP, TRACP5a, TRACP5b, TRAP, TrATPase
Gene Symbols ACP5
Host Species Mouse
Immunogen Recombinant full-length human TRACP/PAP/ACP5 protein (Uniprot: P13686)
Purification Method Protein A or G purified
Quantity 0.1 mL
Regulatory Status RUO
Research Discipline Protein Phosphatase
Primary or Secondary Primary
Test Specificity It recognizes a protein of 35kDa, which is identified as tartrate-resistant acid phosphatase (TRAcP). It exists as two isoforms (5a and 5b). This monoclonal antibody reacts with both the isoforms. Serum TRAcP 5a is secreted by macrophages and dendritic cells and increased in many patients of rheumatoid arthritis.Serum TRAcP 5b is produced from osteoclasts and elevated during bone resorption. TRAcP is an iron containing glycoprotein, which catalyzes the conversion of orthophosphoric monoester to alcohol and orthophosphate. It is the most basic of the acid phosphatases and is the only form not inhibited by L(+)-tartrate. TRAcP is synthesized as a latent proenzyme and is activated by proteolytic cleavage and reduction. Normally, TRAcP is highly expressed by osteoclasts, activated macrophages, neurons and endometrium during pregnancy. Expression of TRAcP is increased in certain pathological conditions such as Leukemic Reticuloendotheliosis (Hairy Cell Leukemia), Gauchers Disease, HIV-induced Encephalopathy, Osteoclastoma and in osteoporosis and metabolic bone diseases. Anti-TRAcP antibody labels the cells of Hairy Cell Leukemia (HCL) with a high degree of sensitivity and specificity. Other cells stained with this antibody are tissue macrophages and osteoclasts.
Target Species Human, Mouse, Rat
Content And Storage Store at 4°C in the dark.
Isotype IgG1 κ
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