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Invitrogen™ TRADD Monoclonal Antibody (T.661.2)
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Catalog No. PIMA515063
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100 μL
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Catalog No. Quantity
PIMA515063 100 μL
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Catalog No. PIMA515063 Supplier Invitrogen™ Supplier No. MA515063
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Description

Rabbit Monoclonal Antibody

It is not recommended to aliquot this antibody.

TRADD (Tumor necrosis factor receptor type 1-associated DEATH domain protein) is an important mediator of FAS and TNFR1 associated apoptotic signaling. The nuclear form acts as a tumor suppressor by preventing ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A by TRIP12. TRADD acts by interacting with TRIP12 and leading to the disruption of the interaction between TRIP12 and isoform p19ARF/ARF of CDKN2A. TRADD acts as an adapter molecule for TNFRSF1A/TNFR1 that specifically associates with the cytoplasmic domain of activated TNFRSF1A/TNFR1 mediating its interation with FADD. Overexpression of TRADD leads to two major TNF-induced responses - apoptosis and activation of NF-kappa-B.
TRUSTED_SUSTAINABILITY

Specifications

Antigen TRADD
Applications Immunoprecipitation, Western Blot
Classification Monoclonal
Clone T.661.2
Conjugate Unconjugated
Formulation 0.01M HEPES with 100 μg/mL BSA, 50% glycerol, 0.15M NaCl and <0.02% sodium azide; pH 7.5
Gene TRADD
Gene Accession No. Q15628
Gene Alias 9130005N23Rik; AA930854; Hs.89862; Hs89862; MGC11078; TNF receptor 1 associated signal transducer; TNFR1-associated DEATH domain protein; TNFRSF1A associated via death domain; TNFRSF1A-associated via death domain; TRADD; tumor necrosis factor receptor type 1 associated death domain protein; tumor necrosis factor receptor type 1-associated DEATH domain protein; tumor necrosis factor receptor-1-associated protein
Gene Symbols TRADD
Host Species Rabbit
Immunogen Synthetic peptide corresponding to residues surrounding glycine 227 of human TRADD.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 8717
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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