Invitrogen™ TRADD Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA588134

Catalog No. PIPA588134

Description

Positive Samples: MCF7, Jurkat; Cellular Location: Cytoplasm, Nucleus, cytoskeleton Immunogen sequence: AQTFLFQGQP VVNRPLSLKD QQTFARSVGL KWRKVGRSLQ RGCRALRDPA LDSLAYEYER EGLYEQAFQL LRRFVQAEGR RATLQRLVEA LEENELTSLA EDLLGLTDPN GGLA.

TRADD (Tumor necrosis factor receptor type 1-associated DEATH domain protein) is an important mediator of FAS and TNFR1 associated apoptotic signaling. The nuclear form acts as a tumor suppressor by preventing ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A by TRIP12. TRADD acts by interacting with TRIP12 and leading to the disruption of the interaction between TRIP12 and isoform p19ARF/ARF of CDKN2A. TRADD acts as an adapter molecule for TNFRSF1A/TNFR1 that specifically associates with the cytoplasmic domain of activated TNFRSF1A/TNFR1 mediating its interation with FADD. Overexpression of TRADD leads to two major TNF-induced responses - apoptosis and activation of NF-kappa-B.

Specifications

• Antigen: TRADD
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: TRADD
• Gene Alias: 9130005N23Rik; AA930854; Hs.89862; Hs89862; MGC11078; TNF receptor 1 associated signal transducer; TNFR1-associated DEATH domain protein; TNFRSF1A associated via death domain; TNFRSF1A-associated via death domain; TRADD; tumor necrosis factor receptor type 1 associated death domain protein; tumor necrosis factor receptor type 1-associated DEATH domain protein; tumor necrosis factor receptor-1-associated protein
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 8717
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot
• Concentration: 2.52 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: Q15628
• Gene Symbols: TRADD
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 199-312 of human TRADD (NP_0037801).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG