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Invitrogen™ TRADD Polyclonal Antibody
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Catalog No. PIPA598439
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100 μg
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PIPA598439 100 μg
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Catalog No. PIPA598439 Supplier Invitrogen™ Supplier No. PA598439
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Description

Rabbit Polyclonal Antibody

TRADD Polyclonal Antibody for Western Blot, ICC/IF, IHC (P), IP, ELISA

TRADD (Tumor necrosis factor receptor type 1-associated DEATH domain protein) is an important mediator of FAS and TNFR1 associated apoptotic signaling. The nuclear form acts as a tumor suppressor by preventing ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A by TRIP12. TRADD acts by interacting with TRIP12 and leading to the disruption of the interaction between TRIP12 and isoform p19ARF/ARF of CDKN2A. TRADD acts as an adapter molecule for TNFRSF1A/TNFR1 that specifically associates with the cytoplasmic domain of activated TNFRSF1A/TNFR1 mediating its interation with FADD. Overexpression of TRADD leads to two major TNF-induced responses - apoptosis and activation of NF-kappa-B.
TRUSTED_SUSTAINABILITY

Specifications

Antigen TRADD
Applications ELISA, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot, Immunocytochemistry, Western Blot
Classification Polyclonal
Concentration 2.72 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.03% ProClin 300; pH 7.4
Gene TRADD
Gene Accession No. Q15628
Gene Alias 9130005N23Rik; AA930854; Hs.89862; Hs89862; MGC11078; TNF receptor 1 associated signal transducer; TNFR1-associated DEATH domain protein; TNFRSF1A associated via death domain; TNFRSF1A-associated via death domain; TRADD; tumor necrosis factor receptor type 1 associated death domain protein; tumor necrosis factor receptor type 1-associated DEATH domain protein; tumor necrosis factor receptor-1-associated protein
Gene Symbols TRADD
Host Species Rabbit
Immunogen Recombinant Human Tumor necrosis factor receptor type 1-associated DEATH domain protein (1-312AA).
Purification Method Protein G
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 246756, 8717
Target Species Human, Rat
Content And Storage -20°C or -80°C if preferred
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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