TRADD Rabbit anti-Human, Polyclonal, Bioss

Catalog No.	Quantity
50-198-1884	100 μL

Catalog No. 50-198-1884 Supplier Bioss Supplier No. BS1202R

Description

Rabbit Polyclonal Antibody

TRADD (Tumor necrosis factor receptor type 1-associated DEATH domain protein) is an important mediator of FAS and TNFR1 associated apoptotic signaling. The nuclear form acts as a tumor suppressor by preventing ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A by TRIP12. TRADD acts by interacting with TRIP12 and leading to the disruption of the interaction between TRIP12 and isoform p19ARF/ARF of CDKN2A. TRADD acts as an adapter molecule for TNFRSF1A/TNFR1 that specifically associates with the cytoplasmic domain of activated TNFRSF1A/TNFR1 mediating its interation with FADD. Overexpression of TRADD leads to two major TNF-induced responses - apoptosis and activation of NF-kappa-B.

Specifications

• Antigen: TRADD
• Applications: Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
• Classification: Polyclonal
• Concentration: 1 μg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
• Gene: TRADD
• Gene Accession No.: Q15628
• Gene Alias: 9130005N23Rik; AA930854; Hs.89862; Hs89862; MGC11078; TNF receptor 1 associated signal transducer; TNFR1-associated DEATH domain protein; TNFRSF1A associated via death domain; TNFRSF1A-associated via death domain; Tradd; tumor necrosis factor receptor type 1 associated death domain protein; Tumor necrosis factor receptor type 1-associated DEATH domain protein; tumor necrosis factor receptor-1-associated protein
• Gene Symbols: TRADD
• Host Species: Rabbit
• Immunogen: KLH conjugated synthetic peptide derived from mouse of mouse TRADD.
• Purification Method: Protein A
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 8717
• Target Species: Human
• Content And Storage: -20°C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG