Invitrogen™ TRAF1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5105281

Catalog No. PIPA5105281

Description

Antibody detects endogenous levels of total TRAF1.

The protein encoded by this gene is a member of the TNF receptor (TNFR) associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from various receptors of the TNFR superfamily. This protein and TRAF2 form a heterodimeric complex, which is required for TNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB. The protein complex formed by this protein and TRAF2 also interacts with inhibitor-of-apoptosis proteins (IAPs), and thus mediates the anti-apoptotic signals from TNF receptors. The expression of this protein can be induced by Epstein-Barr virus (EBV). EBV infection membrane protein 1 (LMP1) is found to interact with this and other TRAF proteins; this interaction is thought to link LMP1-mediated B lymphocyte transformation to the signal transduction from TNFR family receptors. Three transcript variants encoding two different isoforms have been found for this gene.

Specifications

• Antigen: TRAF1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: TRAF1
• Gene Alias: 4732496E14Rik; EBI6; Epstein-Bar virus-induced protein 6; Epstein-Barr virus-induced protein 6; MGC:10353; TNF receptor associated factor 1; TNF receptor-associated factor 1; Traf1
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 22029, 687813, 7185
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: P39428, Q13077
• Gene Symbols: TRAF1
• Immunogen: A synthesized peptide derived from human TRAF1(Accession Q13077), corresponding to amino acid residues Q372-T416.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov