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Invitrogen™ TRAF2 Polyclonal Antibody
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Catalog No. PIPA5120687
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PIPA5120687 100 μL
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Catalog No. PIPA5120687 Supplier Invitrogen™ Supplier No. PA5120687
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Description

Rabbit Polyclonal Antibody

Positive test controls include: 293T, rat testis, mouse thymus. The target is usually found in the following locations: Cytoplasm. Immunogen sequence: DGCGKKKIPR EKFQDHVKTC GKCRVPCRFH AIGCLETVEG EKQQEHEVQW LREHLAMLLS SVLEAKPLLG DQSHAGSELL QRCESLEKKT ATFENIVCVL NREVERVAMT AEACSRQHRL DQDKIEALSS KVQQLERSIG LKDLAMADLE QKVLEMEAST Y.

Tumor necrosis factor (TNF) receptor associated factors (TRAFs) were initially discovered as adaptor proteins that link the TNF receptor superfamily to signaling pathways and are thus important regulators of cell death and cellular response to stress. TRAF proteins share a homology region that allows them to bind to cell receptors and other TRAF proteins, causing the activation of different signal cascades depending on the TRAFs involved. For example, TRAF2 and TRAF3 directly bind to the CD40, a NF receptor superfamily member involved in inducing B cell immunity, and are critical for NF-kappa-B activation in mouse B lymphocytes. TRAF2 along with TRAF6 has also been shown to be required for CD40 signaling in nonhemopoietic cells. TRAF2 also interacts with the TRFR superfamily member lymphotoxin-beta receptor (LTbetaR) in association with TRAF3 and the apoptosis inhibitors cIAP1 and Smac.
TRUSTED_SUSTAINABILITY

Specifications

Antigen TRAF2
Applications ELISA, Western Blot
Classification Polyclonal
Concentration 2.19 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.09% sodium azide; pH 7.3
Gene TRAF2
Gene Accession No. P39429, Q12933
Gene Alias AI325259; E3 ubiquitin-protein ligase TRAF2; MGC:45012; OTTHUMP00000064745; RING-type E3 ubiquitin transferase TRAF2; TNF receptor associated factor 2; Tnf receptor-associated factor 2; TRAF2; TRAP; TRAP3; tumor necrosis factor type 2 receptor associated protein 3; tumor necrosis factor type 2 receptor-associated protein 3
Gene Symbols TRAF2
Host Species Rabbit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 190-350 of human TRAF2 (NP_066961.2).
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 22030, 311786, 7186
Target Species Human, Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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