TRAF3 Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Supplier:  Thermo Scientific PA587516

Catalog No. PIPA587516

Description

Immunogen sequence: MESSKKMDSP GALQTNPPLK LHTDRSAGTP VFVPEQGGYK EKFVKTVEDK YKCEKCHLVL CSPKQTECGH RFCESCMAAL LSSSSPKCTA CQESIVKDKV; Positive Samples: Mouse brain, Rat brain; Cellular Location: Cytoplasm, Endosome, Mitochondrion

Tumor necrosis factor (TNF) induced signaling is mediated through association of TNF receptor (TNFR) with adaptor proteins, such as TNF receptor associated proteins (TRAFs). TRAFs form a family of cytoplasmic adapter proteins that mediate signal transduction from many members of the TNF-receptor superfamily (e. g. RANK, CD30, CD40, etc. ) and the interleukin-1 receptor. The carboxy-terminal region of TRAFs is required for self-association and interaction with receptor cytoplasmic domains following ligand-induced oligomerization. Recent molecular cloning studies have lead to identification of six TRAFs (TRAF1-TRAF6). TRAF3, originally named CRAF1, interacts directly with the CD40 cytoplasmic tail through a region of similarity to the tumor necrosis factor-alpha (TNF-alpha) receptor-associated factors. TRAF3 binds only a single site, which contains the sequence PEQET, whereas TRAF1 and TRAF2 are capable of binding to either the PEQET site or an additional downstream domain.

Specifications

• Antigen: TRAF3
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: TRAF3
• Gene Alias: AI528849, amn, CAP1, CAP-1, CD40 associated protein 1, CD40 binding protein, CD40 receptor associated factor 1, CD40 receptor-associated factor 1, CD40-binding protein, CD40BP, CRAF1, IIAE5, LAP1, LMP1-associated protein 1, RING-type E3 ubiquitin transferase TRAF3, T-BAM, TNF receptor associated factor 3, Tnf receptor-associated factor 3, TRAF3, Trafamn
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 7187
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Western Blot
• Concentration: 0.19 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide, pH 7.3
• Gene Accession No.: Q13114
• Gene Symbols: TRAF3
• Immunogen: A synthetic peptide corresponding to a sequence within amino acids 1-100 of human TRAF3 (NP_0032912)
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG