Invitrogen™ TRAF3IP1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA530507

Catalog No. PIPA530507

Description

Recommended positive controls: U87-MG, mouse testis, rat testis. Predicted reactivity: Bovine (85%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Tumor necrosis factor receptor (TNFR) superfamily members transmit signals regulating proliferation, differentiation and apoptosis in various types of cells. TNFR-associated factors (TRAFs) are a family of proteins that were initially discovered as downstream signal transducers of the TNFR superfamily. TRAF3 contains an N-terminal ring finger/zinc finger region that is thought to be essential for downstream signaling. MIP-T3 is associated with TRAF3. MIP-T3 binds to taxol-stabilized microtubules and to tubulin in vitro, and MIP-T3 recruits TRAF3 to microtubules when both proteins are overexpressed. The MIP-T3/TRAF3 interaction requires the coiled-coil TRAF-N domain of TRAF3. This interaction may provide a novel mechanism in sequestering TRAF3 to the cytoskeletal network.

Specifications

• Antigen: TRAF3IP1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: TRAF3IP1
• Gene Alias: 3930402D05Rik; AU041749; IFT54; interleukin 13 receptor alpha 1-binding protein-1; interleukin-13 receptor alpha 1-binding protein 1; Intraflagellar transport protein 54 homolog; microtubule interacting protein that associates with TRAF3; microtubule-interacting protein associated with TRAF3; microtubule-interacting protein that associates with TRAF3; MIPT3; MIP-T3; SLSN9; TNF receptor-associated factor 3 interacting protein 1; TRAF3 interacting protein 1; TRAF3-interacting protein 1; TRAF3IP1
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 26146, 363286, 74019
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1 mg/mL
• Formulation: 0.1M tris glycine with 20% glycerol and 0.01% thimerosal; pH 7
• Gene Accession No.: Q149C2, Q5XIN3, Q8TDR0
• Gene Symbols: TRAF3IP1
• Immunogen: Recombinant protein encompassing a sequence within the N-terminus region of human TRAF3IP1. The exact sequence is proprietary.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov