Invitrogen™ TRAF4 Recombinant Rabbit Monoclonal Antibody (8F2O5)

Rabbit Recombinant Monoclonal Antibody

Supplier:  Invitrogen™ MA551442

Catalog No. FEMA551442

Description

Immunogen sequence: SHQYQCPRLP VACPNQCGVG TVAREDLPGH LKDSCNTALV LCPFKDSGCK HRCPKLAMAR HVEESVKPHL AMMCALVSRQ RQELQELRRE LEELSVGSDG VLIWKIGSYG RRLQEAKAKP NLECFSPAFY THKYGYKLQV SAFLNGNGSG EGTHLSLYIR VLPGAFDNLL EWPFARRVTF SLLDQSDPGL AKPQHVTETF HPDPNWKNFQ KPGTWRGSLD ESSLGFGYPK FISHQDIRKR NYVRDDAVFI RAAVELPRKI LS.

The tumor necrosis factor (TNF) receptor superfamily is composed of several type I integral membrane glycoproteins that exhibit homology in their cystine rich extracellular domains. Members of this family include TNF-RI, TNF-RII and CD40. Ligands for these receptors can be small, secreted proteins, such as TNF, or type II integral membrane proteins, as is the case for the CD40 ligand, CD40L. While the signal transduction mechanism of the TNF receptor superfamily is poorly understood, activation of TNF-R or CD40 have been shown to induce the nuclear translocation of NFkB. Members of the TRAF (TNF receptor-associated factor) family have been implicated in this process. Four members have thus far been described and are designated TRAF1, TRAF2, TRAF3 (variously referred to as CRAF1, LAP1 or CD40bp) and TRAF4. TRAF4, originally termed CART1, is specifically expressed in breast carcinomas, and is localized to the nucleus in such tissues.

Specifications

• Antigen: TRAF4
• Classification: Recombinant Monoclonal
• Concentration: 0.24 mg/mL
• Formulation: PBS with 0.05% BSA, 50% glycerol and 0.05% ProClin 300; pH 7.3
• Gene Accession No.: Q61382, Q9BUZ4
• Gene Symbols: TRAF4
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 209-470 of human TRAF4 (NP_004286.2).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Format: Liquid

• Applications: ELISA, Western Blot
• Clone: 8F2O5
• Conjugate: Unconjugated
• Gene: TRAF4
• Gene Alias: A530032M13Rik; Cart1; cysteine-rich domain associated with ring and TRAF domain; cysteine-rich domain associated with RING and Traf domains protein 1; Cysteine-rich motif associated to RING and Traf domains protein 1; malignant 62; metastatic lymph node gene 62 protein; MLN 62; MLN62; msp2; RING finger protein 83; RNF83; RNF83malignant 62; TNF receptor associated factor 4; TNF receptor-associated factor 4; tnf receptor-associated factor 4b; traf4; TRAF4 protein; TRAF4 variant 6; traf4b; tumor necrosis receptor-associated factor 4A
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 22032, 303285, 9618
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid
• Isotype: IgG