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Invitrogen™ TRAF5 Polyclonal Antibody
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Catalog No. PIPA596156
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100 μL
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PIPA596156 100 μL
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Catalog No. PIPA596156 Supplier Invitrogen™ Supplier No. PA596156
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: MAYSEEHKGM PCGFIRQNSG NSISLDFEPS IEYQFVERLE ERYKCAFCHS VLHNPHQTGC GHRFCQHCIL SLRELNTVPI; Positive Samples: OVCAR3; Cellular Location: Cytoplasm, cytosol.

Tumor necrosis factor (TNF) induced signaling is mediated through association of TNF receptor (TNFR) with adaptor proteins, such as TNF receptor associated proteins (TRAFs). TRAFs form a family of cytoplasmic adapter proteins that mediate signal transduction from many members of the TNF-receptor superfamily (e. g. RANK, CD30, CD40, etc. ) and the interleukin-1 receptor. The carboxy-terminal region of TRAFs is required for self-association and interaction with receptor cytoplasmic domains following ligand-induced oligomerization. Recent molecular cloning studies have lead to identification of six TRAFs (TRAF1-TRAF6) (1-4). TRAF5 is a 558-amino acid protein. TRAF5 is implicated in NF-kB and c-Jun NH(2)-terminal kinase/stress-activated protein kinase activation by members of the TNF receptor superfamily, including CD27, CD30, CD40, and lymphotoxin-beta receptor. Targeted disruption of TRAF5 gene causes defects in CD40-CD27 mediated lymphocyte activation (5).
TRUSTED_SUSTAINABILITY

Specifications

Antigen TRAF5
Applications ELISA, Western Blot
Classification Polyclonal
Concentration 1.87 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
Gene TRAF5
Gene Accession No. O00463
Gene Alias 2700049M22Rik; AI875481; AU022477; BH3 interacting domain death agonist; BH3-interacting domain death agonist; BH3-interacting domain death agonist p11; BH3-interacting domain death agonist p13; BH3-interacting domain death agonist p15; BID; MGC:39780; p11 BID; p13 BID; p15 BID; p22 BID; RING finger protein 84; RNF84; TNF receptor associated factor 5; TNF receptor-associated factor 5; Traf5
Gene Symbols TRAF5
Host Species Rabbit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 1-80 of human TRAF5 (NP_6657021).
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 7188
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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