Invitrogen™ TRAIL-R3 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA588119

Catalog No. PIPA588119

Description

Immunogen sequence: VEEFGANATV ETPAAEETMN TSPGTPAPAA EETMNTSPGT PAPAAEETMT TSPGTPAPAA EETMTTSPGT PAPAAEETMT TSPGTPASS Positive Samples: LO2, Mouse lung, Rat lung; Cellular Location: Cell membrane, GPI-anchor, Lipid-anchor.

TRAIL-R3 (CD263) is a member of the TNF-receptor superfamily. This receptor contains an extracellular TRAIL-binding domain and a transmembrane domain, but no cytoplasmic death domain. This receptor is not capable of inducing apoptosis, and is thought to function as an antagonistic receptor that protects cells from TRAIL-induced apoptosis. This gene was found to be a p53-regulated DNA damage-inducible gene. The expression of this gene was detected in many normal tissues but not in most cancer cell lines, which may explain the specific sensitivity of cancer cells to the apoptosis-inducing activity of TRAIL.

Specifications

• Antigen: TRAIL-R3
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: TNFRSF10C
• Gene Alias: Antagonist decoy receptor for TRAIL/Apo-2L; CD263; cytotoxic TRAIL receptor-3; DCR1; DCR1-TNFR; Decoy receptor 1; decoy TRAIL receptor without death domain; LIT; lymphocyte inhibitor of TRAIL; MGC149501; MGC149502; TNF receptor superfamily member 10c; TNF-related apoptosis-inducing ligand receptor 3; TNFRSF10C; TRAIL receptor 3; TRAIL receptor without an intracellular domain; TRAILR3; TRAIL-R3; TRID; Tumor necrosis factor receptor superfamily member 10C; tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain; UNQ321/PRO366
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 8794
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot
• Concentration: 0.51 mg/mL
• Formulation: PBS with 50% glycerol and 0.09% sodium azide; pH 7.3
• Gene Accession No.: O14798
• Gene Symbols: TNFRSF10C
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 150-238 of human TNFRSF10C (NP_0038322).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Mouse, Rat, Rat
• Product Type: Antibody
• Isotype: IgG